The
Longevity Stack
If you are searching for the best longevity supplements to support healthy ageing, energy, and long-term wellbeing, it can be difficult to know where to start. The supplement market is full of bold claims, but not all products target the key biological pathways linked to ageing. This guide breaks down a tiered longevity stack using DoNotAge supplements, focusing on evidence-based compounds that support NAD+ levels, mitochondrial function, metabolic health, inflammation, and cellular repair. Whether you are building a simple foundational routine or exploring advanced anti-ageing strategies, this page will help you understand which supplements matter most, how they work together, and how to structure an effective longevity protocol.
Hi, I’m Zib
I’m the Longevity Researcher and I’m currently completing a PhD in Longevity, where I study the biological pathways that determine how well we age.
My research focuses on the core mechanisms of ageing, including metabolism, autophagy, nutrient sensing, DNA damage, oxidative stress, and epigenetic alterations.
These are the systems that control how quickly we age, how well we function, and how long we stay healthy.
Alongside my PhD, I hold an MSc in Molecular Medicine, a BSc in Human Bioscience, and a Diploma in Clinical Nutrition, and I have over 19 years of experience helping coach people to improve their health in the real world.
How to Use This Stack
Start with Tier 1 (essential health)
Add Tier 2 if you want true longevity optimisation
Layer in Tier 3 for energy and performance
Only explore Tier 4 if you are comfortable with emerging science
This structure avoids the biggest mistake people make: jumping straight into advanced supplements without fixing the basics first
Essential Longevity Stack
Tier 1
If you are looking for the best supplements for overall health and longevity, this is where you start. These are the compounds with the strongest human evidence and the widest impact across multiple systems. Omega-3 fatty acids support cardiovascular health and reduce systemic inflammation, while vitamin D3 combined with K2 and magnesium plays a central role in immune function, bone health, and calcium regulation. Berberine stands out as one of the most effective natural compounds for improving blood sugar control and insulin sensitivity, making it highly relevant for metabolic health and lifespan. This tier alone covers inflammation, nutrient status, and metabolic regulation, which are three of the biggest drivers of ageing.
Omega-3
Vitamin D3 + K2 + Magnesium
Berberine
Advanced Longevity Stack
Tier 2
Once your foundations are covered, this tier targets the core biology of ageing at a deeper cellular level. NMN increases NAD+, a molecule essential for energy production, DNA repair, and cellular signalling, which naturally declines with age. Instead of resveratrol, this stack uses a SIRT6 activator, which focuses more specifically on one of the most important sirtuins linked to genomic stability, DNA repair, and lifespan regulation. SIRT6 plays a key role in maintaining telomere integrity and regulating metabolic health, making it a highly relevant target in longevity research. TMG is included to support methylation, as increasing NAD+ can place additional demand on these pathways over time. If you are looking for advanced anti-ageing supplements that go beyond general health and directly target longevity mechanisms, this stack represents a more precise and next-generation approach.
SIRT6
NMN
TMG
Performance & Energy Optimisation
Tier 3
This tier is ideal if your goal is not just longevity, but also feeling better day-to-day. CoQ10 supports mitochondrial function and is especially important for heart health and energy production. Creatine is one of the most well-researched supplements available, improving both physical performance and cognitive function through its role in ATP regeneration. Ca-AKG is a newer addition to longevity discussions, with animal studies suggesting potential lifespan and healthspan benefits. Together, these supplements target mitochondrial efficiency and cellular energy, which are key factors in both ageing and performance.
CoQ10
Creatine
Ca-AKG
Cellular Clean-up & Longevity Optimisation
Tier 4
This is where things move into more experimental longevity territory, focusing on clearing damaged cells and enhancing cellular recycling. Fisetin has shown senolytic effects in preclinical studies, meaning it may help remove senescent cells that accumulate with age. Spermidine promotes autophagy, the process by which cells repair and recycle components, and has been linked to lifespan extension in model organisms. Quercetin adds anti-inflammatory and antioxidant support, and may complement senolytic strategies. If you are looking into cutting-edge anti-ageing supplements or strategies similar to fasting and cellular rejuvenation, this tier represents that next level.
Fisetin
Spermidine
Quercetin
Sleep & Recovery (Often Overlooked)
Bonus Tier
This is where things move into more experimental longevity territory, focusing on clearing damaged cells and enhancing cellular recycling. Fisetin has shown senolytic effects in preclinical studies, meaning it may help remove senescent cells that accumulate with age. Spermidine promotes autophagy, the process by which cells repair and recycle components, and has been linked to lifespan extension in model organisms. Quercetin adds anti-inflammatory and antioxidant support, and may complement senolytic strategies. If you are looking into cutting-edge anti-ageing supplements or strategies similar to fasting and cellular rejuvenation, this tier represents that next level.
SureSleep
Apigenin
SAVE 10% WITH DISCOUNT CODE: ZIB10 AT DONOTAGE
We are partnered with DoNotAge because we believe in their goal of helping people live healthier for longer. As part of this collaboration, we have secured a 10% off discount code (ZIB10) that you can use when you shop their products.
DoNotAge strives to keep prices fair and invests some of its revenues into further research in the ageing and longevity space. They work with scientists in the field and publish results from third party quality testing, which we value highly.
In 2025 I even took part in a trial with DoNotAge for Nitralis and I was honoured to be a part of their trial to help produce the best longevity products.